BRCA Breast Cancer Genes and Soy
New Breast Cancer Genes, Why Excess Weight is Bad for Breast Cancer Patients, and More
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Beyond BRCA1 and BRCA2
In the mid-nineties, scientists identified two genes—BRCA1 and BRCA2—that, if present, predicted an increased risk for an inherited risk for breast cancer. It was an enormous step—and yet only about 1% of women were affected by it. Researchers have long suspected that there were other genes that conferred risk, but which ones they were remained elusive—until now. On October 23rd, two articles published inNatureandNature Geneticsrevealed that an international team of 550 researchers in six continents, had identified 72 new genes associated with breast cancer, potentially heralding a new age of more targeted breast cancer screening and treatment.
In other breast cancer news...
How Obesity Promotes Breast Cancer Growth--and a Potential new Approach to Treatment
Science has long since established that being obese bad for women with breast cancer. But why? A new study published in the October issue ofCell Metabolismhas offered a theory. Researchers examined the molecular activity of breast cancer cells taken from mice and humans, and found, in obese subjects ,an increase in the release of two proteins, leptin and transforming growth factor beta, into the bloodstream. These proteins inhibit ACC1, a protein that is often found in low amounts in women with breast cancer that has spread, or metastasized. Blocking the pathways that lead to the release of leptin and transforming growth factor beta stopped the cells from going through the process of metastasizing. "Blocking the signaling pathways and switching off the metastasis-related genes could be a therapeutic target," said Stephan Herzig, MD, in a write-up of the news inMedical News Today.
Older Women with Early Breast Cancer are Often Overtreated
In 2013 The American Society for Radiation Therapy issued guidelines suggesting a shorter course of radiation for women over 50 with early stage breast cancer that had not spread. The new guidelines were based on research that found that a longer course was no more beneficial to women than a shorter one, and came with more side effects, such as lymphadema, which can cause painful and long-lasting swelling. Yet a new analysis has found that only 48 percent of older breast cancer patients with early stage cancer get the shorter regimen, despite the additional cost involved,the inconvenience to the patients, and the increased risk for side effects like lymphadema. These findings "reflect how hard it is to change practice," Dr.
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